A novel mechanism of control of NFkB activation and inflammation involving A2B adenosine receptors
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چکیده
o u rn a l o f C e ll S c ie n c e A novel mechanism of control of NFkB activation and inflammation involving A2B adenosine receptors Ying Sun, Yuanyuan Duan, Anna S. Eisenstein, Wenbao Hu, Adrien Quintana, Wai Kwan Lam, Yan Wang, Zhenguo Wu, Katya Ravid and Pingbo Huang* Division of Life Science, and State Key Laboratory of Molecular Neuroscience, Hong Kong University of Science and Technology, Hong Kong, People’s Republic of China Department of Medicine and Biochemistry, and Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, MA 02118, USA
منابع مشابه
Thymoquinone, the main constituent of Nigella sativa, affects adenosine receptors in asthmatic guinea pigs
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متن کاملA novel mechanism of control of NFκB activation and inflammation involving A2B adenosine receptors.
The nuclear factor kappa B (NFκB) pathway controls a variety of processes, including inflammation, and thus, the regulation of NFκB has been a continued focus of study. Here, we report a newly identified regulation of this pathway, involving direct binding of the transcription factor NFκB1 (the p105 subunit of NFκB) to the C-terminus of the A(2B) adenosine receptor (A(2B)AR), independent of lig...
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Introduction:Adenosine as a potent vasodilator has physiological role in regulation of regional cerebral blood flow (rCBF). Metod: Laser-Dِoppler flowmetry technique was used to study pial vessels blood flow responses to adenosine receptors agonists and antagonist. Male Sprague Dawley rats (250-350g) that were housed in standard conditions, were anesthetized with Urethane (1.5g/kg). Adenosine ...
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تاریخ انتشار 2012